We use high-throughput protein interactions technologies to understand how eukaryotic cells function. We perturb cellular context using viral infections and genes knockdown to elucidate potential therapeutic targets.
In collaboration with the New York University of Abu Dhabi, our team co-led to demonstrate that nanoparticles can be used to block SARS CoV-2 replication in a 3D lung epithelium. Those data encourage nanoparticle technology to be used as a new treatments.
In close collaboration with the laboratory of Algal Systems and Synthetic Biology from the New York University of Abu Dhabi, our lab contributed to better understand the macroalgae genetic evolution and morphology diversity.
In close collaboration with New York University of Abu Dhabi, our lab lead the new edition of this conference to expose new expertise and research in drug design field to encourage new drug discovery and share new discoveries with the scientific comunity
HTLV-1 was discovered in 1979 (Poiesz et al. 1980). For the past 40 years, scientists have described the role of HTLV-1 Tax-1, and HBZ encoded proteins in the perturbation of signaling pathways and ATL pathogenesis.
The endoplasmic reticulum (ER) is a dynamic tubular network that serves many roles in the cell including viral trafficking; protein synthesis, lipid metabolism and calcium storage. We are interested in the modulation of ER structure, stability and dynamics by ER-resident glycosyltransferases.
Our goal in this project is to develop a highly parallel and HT assay capable of screening hundreds of thousands of compounds to identify potential iPPIs for cancer immunotherapy.
Several molecular mechanisms that govern cellular life can be surveyed by examining the behavior of viral genes and the perturbations of cell survival and fate following an infection.
Our longstanding interest is to better understand cell biology and viral interactome networks with their respective host cells.
